Research in Hepatology & Liver Disease
Dr. Pascal's research focuses on hepatocellular carcinoma (liver cancer) — particularly risk stratification, early detection biomarkers, and therapeutic response prediction in Chinese patient populations. His work bridges clinical hepatology with translational molecular research.
Areas of Investigation
Risk stratification, recurrence prediction, and biomarker identification in HBV-related and NASH-related liver cancer.
Non-alcoholic fatty liver disease (NAFLD) to cirrhosis transition mechanisms and clinical staging validation.
Identifying molecular markers that predict response to systemic therapy in advanced hepatocellular carcinoma.
Comparative epidemiology and clinical outcome differences for African patients treated within the Chinese healthcare system.
Research Publications
doi:10.1007/s12072-025-10786-7 - ArchitectureBiomarker response model
- DesignAdvanced HCC therapeutic-response analysis
- ResultsInflammation-response signal placeholder
- ArchitectureRecurrence-risk stratification
- DesignRepeat hepatectomy vs. salvage liver transplant cohort
- ResultsNLR as a predictor of post-recurrence outcomes
- ArchitectureForensic case-series analysis
- DesignRetrospective autopsy review, Shanghai region
- ResultsLow-COHb saturation cases re-characterised
Clinical & Research Experience
Skills & Competencies
- —Murine hepatic ischemia-reperfusion
- —Intrasplenic tumor injection
- —Retro-orbital venous sampling
- —Liver perfusion
- —Microsurgical dissection
- —THP-1 macrophage polarization
- —ELISA
- —Western blot
- —PCR
- —TUNEL apoptosis
- —CCK-8 viability
- —Transwell migration / invasion
- —RNA-sequencing interpretation
- —Mass spectrometry proteomics
- —IHC / IF markers
- —CRISPR/Cas9 (conceptual design)
- —RStudio · GraphPad Prism · SPSS
- —Biomarker study design
- —Retrospective cohort analysis
- —EMR dataset management
- —GCP compliance
- —Scientific writing
Interested in Research Collaboration?
Open to joint research, co-authorship, and data-sharing opportunities in hepatology and liver disease.
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