Translational Inquiry
Translational laboratory investigation and biomarker analysis.
Laboratory investigation connected to biomarker analysis, mechanism-driven interpretation, and clinically meaningful questions in liver disease and cancer.
Research & Publications
Translational oncology, hepatobiliary surgery, and transplant immunology with clinical relevance.
Clinical Grounding
Clinical perspective grounded in surgery and patient outcomes.
Research questions shaped by hepatobiliary surgery, transplant realities, and patient outcomes rather than abstract bench work alone.
Immunology & Data
Molecular and immunology-focused research workflows.
Molecular workflows, immunology-focused analysis, and multi-source datasets used to support stronger clinical interpretation.
Research Focus
Primary Scientific Direction
My work connects laboratory science and clinical decision-making in hepatocellular carcinoma (HCC), liver transplantation, and immuno-oncology.
- IL-6/JAK/STAT3 pathway biology in liver cancer
- Hepatic ischemia-reperfusion injury models
- CAR-T therapy evaluation in advanced HCC
Methods and Data Strategy
Research design integrates preclinical models, translational datasets, and statistical interpretation to support clinically actionable findings.
- Biomarker discovery for post-transplant outcomes
- Multi-omics analysis (RNA-seq, IHC, proteomics)
- Clinical cohort analysis and outcome modeling
Selected Publications
The Impact of Cold Ischemia Time and Microvascular Invasion on HCC Recurrence Post-Liver Transplantation
Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth Through STING-Mediated Type I Interferon Response
Predictive Value of Neutrophil-to-Lymphocyte Ratio in Recurrent HCC After Repeat Hepatectomy or Salvage Liver Transplantation
Acute Carbon Monoxide Poisoning With Low Saturation of Carboxyhaemoglobin: A Forensic Retrospective Study in Shanghai, China
Research Experience Timeline
| Period | Role | Institution |
|---|---|---|
| Sep 2023 - Present | Translational R&D Researcher - Hepatobiliary Oncology & Transplant Immunology | Fudan University Zhongshan Hospital |
| Aug 2024 - Sep 2025 | Research Associate - Post-Transplant Immunopathology & GVHD Study | Fudan University Zhongshan Hospital |
| Jul 2021 - Aug 2021 | Clinical Research Associate Intern - CAR-T Cell Therapy Program | Shanghai Origin Cell Therapeutics |
| 2021 | Undergraduate Research Analyst - Forensic Epidemiology & Biomarker Study | Fudan University Forensic Science |
Technical Skills
In Vivo Models
Murine hepatic ischemia-reperfusion, intrasplenic tumor injection, retro-orbital venous sampling, liver perfusion, and microsurgical dissection.
Cell & Molecular
THP-1 macrophage polarization, HCC co-culture, hypoxia chamber, ELISA, TUNEL apoptosis, Western blot, PCR, CCK-8, and Transwell migration/invasion.
Genomics / Omics
RNA-sequencing interpretation, mass spectrometry proteomics, IHC/IF markers, and CRISPR/Cas9 conceptual design.
Data & Statistics
RStudio, GraphPad Prism, SPSS, EMR dataset management, GCP compliance, and trial documentation.